This match's only significance is to give Bangladesh the chance to attune themselves to white-ball cricket in South African conditions.
But, for De Villiers and Duminy, the game looms larger than it has a right to.
It will be De Villiers' first game since the third T20 against England in Cardiff in June, the Titans' first-class match against the Warriors in Benoni at the weekend excepted.
Duminy last played at any significant level in the first Test against England at Lord's in July, which was followed in September by his retirement from Test and first-class cricket.
For De Villiers, who has chosen not to play in South Africa's last 17 Tests, this is a chance to remind himself and the public what it means to be part of a South Africa team ahead of his anticipated comeback in the format against India in January.
Duminy will want to underline his white-ball worth now that he has given up a third of his international involvement.
Like comets, players come and go. Even the best and brightest, like De Villiers and Duminy.
They came a long time ago. Might they go in a blaze of glory?